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Citalopram 20 mg online. Efficacy and safety of fluvastatin Safety and efficacy profiles of fluvastatin using the updated version of monoclonal antibody fluvastatin in depression have been compared over a 14-year period, with approximately 5500 subjects on fluvastatin-containing SSRIs.8 This cohort included men and women from the United States, Ireland, Kingdom, Netherlands, and Sweden, the majority were aged under 60 years. Baseline characteristics included gender, age (mean ± SD: 62.1 13.8 y and 46.5 ± 12.4 for men and women), duration of illness (mean ± SD: 4.9 0.65 mo and 3.5 ± 0.66 for men and women), illness duration severity (4.5 ± 0.68 and 4.8 0.76 days for men and women). Participants completed a psychiatric interview and an imaging test for depression. All the randomized patients were then assigned, over the course of treatment, to receive fluvastatin 20 80 mg/day or placebo. Outcomes included changes in response to treatment and adverse events at the end of treatment. The median starting dose of fluvastatin 20 mg/day was 9.32 mg, and the median starting dose of fluvastatin 80 mg/day was 6.96 mg. Among the 1338 patients in fluvastatin 20-mg group, 18.9% discontinued the study due to adverse events. The most common medical events reported in the fluvastatin 20-mg group included following: 1) abdominal pain, 7%; 2) diarrhea, 3) abdominal discomfort or bloating, 6%; 4) headache, and 5) insomnia, 6%. All adverse events occurred in fewer than 1 100 patients taking fluvastatin 20 mg/day compared with 4 in 100 taking placebo. Table 2. Common Adverse Effects in Randomized Patients During the Study. Compared with placebo, fluvastatin increased the proportion of patients in fluvastatin 20-mg group who exhibited a sustained clinical response (defined as a 50% decrease in antidepressant response from baseline on the Hamilton Depression Rating Scale [HDRS] after 12 weeks of treatment) from 32% at the initial dose to 51% after placebo at 12 weeks (P = 0.023). Safety was similar between the groups, and there were no drug-related serious adverse events reported. An analysis of relapse during treatment showed that fluvastatin 20 mg/day patients had a reduced risk of relapse 20% compared with placebo (hazard ratio, 0.62 [95% confidence interval, 0.26 to 1.20]), after 6 months of treatment (hazard ratio, 0.60 [0.30 to 0.94]), and after 12 months of treatment (hazard ratio, 0.56 [0.31 to 0.97]) (P = 0.001). Adverse reactions that were considered consistent with the development of clinically significant drug-related intolerance (eTable 2 in Supplement 2), which are those that led to ≥1 reduction (decrease in scores) the HDRS on a baseline rating scale of 15 or greater, were.

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